Osteo Bi-Flex Review 2023-Is it good for joint pain?

The most prevalent type of arthritis is osteoarthritis. Some people call it “wear and tear” arthritis or degenerative joint disease. It usually affects the hands, hips, & knees. Osteoarthritis causes the bone beneath the cartilage …

Osteo Bi-Flex Review

The most prevalent type of arthritis is osteoarthritis. Some people call it “wear and tear” arthritis or degenerative joint disease. It usually affects the hands, hips, & knees. Osteoarthritis causes the bone beneath the cartilage in a joint to deteriorate and alter.

Osteo Bi-Flex Triple Strength was developed to bolster your joints’ health and mobility nutritionally. It includes the renowned Joint Shield and glucosamine, which strengthens your joints little by little so your joints can function as they should.

In the following blog, we will dive deep into an unbiased Osteo Bi-Flex review and whether you should consider it a viable medication option.

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Osteo Bi-Flex – The Ins and Outs

A nutritional supplement called Osteo Bi-Flex helps to keep joints healthy. One of the most popular supplements in this group, it is commonly recommended as an over-the-counter remedy for those with knee osteoarthritis. It’s also a smart option to be informed of the components of this supplement and the studies that back up its effectiveness.

As a supplement, Osteo Bi-Flex has not received approval from the Food & Drug Administration. However, the components of the medicine have received enough study.


Multiple component compositions with a range of slight variations are available from Osteo Bi-Flex. Nevertheless, the company touts a select group of substances as the main components.

Joint Shield

Boswellia serrata extract supplemented with a substance called 3-O-acetyl-11-keto-beta-boswellic acid is one of several proprietary blends of substances that make up the core ingredient of Osteo Bi-Flex, “Joint Shield,” which is promoted as the product’s key component (AKBA).

According to reports, 5-loxin is effective in treating knee osteoarthritis. In one trial, reducing inflammation helped individuals with osteoarthritis feel less pain and perform better physically.

Although they choose the side with caution, studies claim it is harmless and may even benefit joint health.

Most Osteo Bi-Flex products contain a “Joint Shield,” while the secondary components vary slightly among them.

To varying degrees, each of these has also been said to have some beneficial effects on osteoarthritis symptoms.


Glucosamine had already long been advocated as a therapy for osteoarthritis alongside chondroitin. Its true efficacy is in question and varies from supplement manufacturer to supplement manufacturer.

Human cartilage naturally contains glucosamine, which is in charge of the fluid around the joints.

Glucosamine is produced in a lab or obtained from shellfish shells when used in supplements.

It could cause issues for those who are allergic to shellfish. If this worries you, it’s crucial to read labels carefully.


Chondroitin, a different organic substance also present in cartilage, aids in water retention in joints. Animal cartilage is the most prevalent source of chondroitin in supplements.

Numerous studies have been conducted on the efficacy of glucosamine and chondroitin.

Studies and tests from supplement producers have proven their efficacy in treating osteoarthritis. Independent groups’ tests, however, have indicated little to no advantage.

UC-II Collagen

It is a type II collagen that hasn’t been denatured and one which has been shown to promote joint health.

Numerous Osteo Bi-Flex products contain it. It is often made from chicken breast cartilage when used in supplements. Independent investigations on the treatment of osteoarthritis using UC-II collagen have produced encouraging results.

A study comparing the effects of UC-II collagen to placebo or a mixture of glucosamine hydrochloride and chondroitin sulfate in patients with mild to moderate knee osteoarthritis found that patients taking UC-II collagen indicated a greater level of physical function, rigidity, and pain.


Methylsulfonylmethane (MSM) is frequently offered as a stand-alone dietary supplement for various illnesses, including osteoarthritis. It is present in several Osteo Bi-Flex products, which usually state “with MSM” only on the packaging.

The sulfur in MSM is something the human body’s connective tissues need. Although one study showed the benefits to really be modest, it is believed to combat inflammation.

It also mentions that there is no known clinical significance between MSM and osteoarthritis.

A word of caution Supplements made entirely of MSM have been known to cause diarrhea and upset stomachs, among other negative effects. Additionally, blood thinners should not be taken with it.

Discuss this with your doctor because the amount of MSM in a certain Osteo Bi-Flex product may not be ideal for you.

Precautions and Interactions

A nutritional supplement is not always safe for you just because it is available over the counter.

Before taking Osteo Bi-Flex, consult your doctor. Given your medical history, current medications, and dietary supplements you may be taking, there may be an element in one of the several formulations that could be troublesome.

There are a few possible issues to be mindful of –


Certain Osteo Bi-Flex products raise an issue with shellfish allergies. Additionally, glucosamine (which is obtained from shellfish) and chondroitin can cause allergic reactions in some people.

Pregnancy or Nursing

It is advised that individuals who are either pregnant or nursing speak with their doctor before using any Osteo Bi-Flex product.

Drug Interactions

This medicine may interact with Mirador (anisindione) and Coumadin (warfarin) anticoagulants. Before taking Osteo Bi-Flex, consult your doctor if you take any drugs.


Glucosamine may raise ocular pressure in people with glaucoma. Before using Osteo Bi-Flex, see your doctor if you have glaucoma. 


Avoid using additional glucosamine or chondroitin-containing products while using Osteo Bi-Flex. An overdose may arise from doing so. Vomiting, diarrhea, jaundice, and a lack of appetite are symptoms of glucosamine toxicity.

Blood Sugar Levels

Glucosamine can change how glucose is metabolized. When using glucosamine-containing products, those with diabetes, prediabetes, or hypoglycemia must keep a closer eye on their blood sugar levels.

Liver Disease

People with chronic liver disease should see their doctor before using glucosamine-containing products.

According to research, glucosamine may cause higher liver enzyme levels in patients with pre-existing liver disease.

An Alternative

Before we dive into the ins and outs of Osteo Bi-Flex, let us take a moment to check out an alternative medication. Physio Flex Pro is such an alternative.

It has been demonstrated the booster is an excellent joint supplement. Physio Flex Pro has components that have been shown to lessen joint inflammation and increase mobility.

Additionally, it has all the necessary ingredients to give you strong joints. This substance maintains joint lubrication and aids in cartilage development. Low levels of selenium increase the risk of osteoarthritis.

Its choice to combine a significant amount of selenium with a balanced dosage of bromelain, as well as glucosamine hydrochloride, sets it apart slightly from other supplements.

In a nutshell, this booster Physio Flex Pro can be your golden pick to recover joint issues!

Frequently Asked Questions

What Osteo Bi-Flex adverse effects are there?

Bloating, nausea, diarrhea, puffy eyelids, hair loss, constipation, gas, and stomach pain are examples of possible Osteo Bi-Flex adverse effects. Infrequent but more severe side effects include allergic responses, limb edema, and abnormal heartbeats.

Does Osteo Bi-Flex restore damage to joints?

Maybe, but not very likely. There is some evidence that the components of Osteo Bi-Flex alone may enhance joint health, increase mobility, and lessen discomfort.

However, no imaging-based before-and-after research studies support the cure of joint injury.

Does Osteo Bi-Flex have an impact on the kidneys?

Possibly. One of the primary components of Osteo Bi-Flex, glucosamine, may damage the kidneys in moderate to high amounts, according to research conducted on animals. It is still being determined, though, whether it will have the same impact on people.

Can glucosamine make you gain weight?

It’s ambiguous. In experiments on animals, glucosamine increased body weight in rodents given a typical diet though not in those given a high-fat diet. Insulin resistance, which would be connected to weight gain, may be facilitated by glucosamine. Human research is required.

Bottom Line

Osteoarthritis is a condition that affects many people, and the regular use of Osteo Bi-Flex has allowed many of these individuals to experience some relief from the symptoms of their condition.

It is formulated in a wide variety of ways, the majority of which ask the user to take just one or two caplets daily. These formulations are available.

Although studies support the benefits of some of the substances present in Osteo Bi-Flex, the effectiveness of the supplements themselves has not been evaluated.

So, after reading this Osteo Bi-Flex review, you are now aware of the components that go into making up this supplement, and you are in a better position to have an informed conversation with your healthcare practitioner about whether or not you should take them.


Jerosch, J. (2011). Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. International Journal of Rheumatology, 2011. https://doi.org/10.1155/2011/969012

Butawan, M., Benjamin, R. L., & Bloomer, R. J. (2017). Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients, 9(3). https://doi.org/10.3390/nu9030290

Gencoglu, H., Orhan, C., Sahin, E., & Sahin, K. (2020). Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals. Animals : an Open Access Journal from MDPI, 10(4). https://doi.org/10.3390/ani10040697

Dr. Matt Boold is a licensed clinical psychologist who conducts structured assessment and psychotherapy with medical patients and mental health consumers in Reno, Nevada. He also conducts original research on posttraumatic stress and emotional regulation in clinical disorders, and he teaches university courses on related topics.

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