Glucuronolactone Uses− Benefits and Side Effects

Have you ever thought about why you feel so lively after an energy drink? Well, one of the most vital components responsible for that is Glucuronolactone. Not just physical, it can improve your mental performance …

Glucuronolactone Uses− Benefits and Side Effects

Have you ever thought about why you feel so lively after an energy drink?

Well, one of the most vital components responsible for that is Glucuronolactone.

Not just physical, it can improve your mental performance as well. You can get tons of benefits from Glucuronolactone; there’s no doubt about that.

Hence, this article will be your ultimate guide if you’re thinking about its supplementation.

This write-up focuses on Glucuronolactone uses, benefits, side effects, and the precautions you need to take while having this.

So, without wasting much time, let’s get into that part right away.

Glucuronolactone Uses, Benefits, and Side Effects – All You Need to Know

You’ll see Glucuronolactone on the labels of various energy-enhancement products.

And even though it naturally occurs in our body, we can take it orally to improve our overall health.

But what is the correct procedure to take it? How do we know if it has any adverse effect or not?

And what kind of benefits can we expect from this ingredient? Well, that’s what we’re about to discuss in the following parts.

How Does Glucuronolactone Work?

Glucuronolactone, or D-glucuronic-gamma-lactone (DGL), is an active ingredient in human bodies in physiological balance with glucuronic acid.

And thanks to its link with glucuronidation, it takes part in improving liver function.

This compound is found and produced in our connective tissues, such as ligaments and cartilage.

You can also get it from your regular diet, but the amount is pretty tiny.

Therefore, you can easily ingest Glucuronolactone supplements without causing any harm to your body.

Benefits of Glucuronolactone

Not just an energy boost, Glucuronolactone comes with a ton of different benefits.

This component has a lot to offer, from enhancing our mental performance to keeping our hearts healthy.

In the following section, we’ve briefly discussed the benefits you can get from Glucuronolactone.

Improves Cardio Vascular Health

With regular dosages of Glucuronolactone, you’ll experience improvement in your cardiovascular system.

It’s an anti-platelet aggregative compound. As a result, this ingredient has the ability to prevent the platelets from sticking together.

And this way, you can reduce the chances of a heart attack or stroke.

Enhances Physical Performance

Well, you can find Glucuronolactone in most energy drinks. So, it can undoubtedly work to enhance your physical performance.

If you’re having a rough day, you can take this to inspire your body to go the extra mile.

But there’s one thing you need to keep in mind. You cannot solely depend on Glucuronolactone to energize your body.

A proper diet is required for that purpose, and you can only use this supplement as a boost.

Aids in Bodybuilding

Glucuronolactone can be combined with other active ingredients, such as caffeine, to improve endurance.

If you’re into intense workout sessions, you can take Glucuronolactone for a boost.

In addition, DGL supports muscle development, which is good news for bodybuilders.

Sometimes we don’t feel inspired enough to go through our cardio exercises.

But when we miss multiple workout sessions, we’ll fail to achieve the physique of our dream.

In that case, Glucuronolactone can really help us to get back on track with its doses of energy.

Improves Mental Performance

Yes, this compound can also improve our mental performance, eliminate brain fog and make our cognitive function sharper.

When you’re feeling confused, stressed, or anxious, Glucuronolactone will elevate your mood so you can chill.

Furthermore, DGL can make our thinking process sharper by increasing alertness in our brains. After ingesting it, we’ll be able to focus on tedious things without trouble.

Supports Joint Health

Glucuronolactone comes with a component named Chondroitin Sulphate. It’s one of the most effective ingredients that improve the conditions of our bone joints.

And Chondroitin Sulphate also takes part in the structure of our cartilages, tendons, and ligaments.

Therefore, if you’re suffering from joint health issues, DGL can be your best shot.

And it also strengthens bones, another fantastic benefit we can enjoy.

Safe Usage of Glucuronolactone

If you take Glucuronolactone within the proper dosage, you won’t face any adverse effects.

But the accurate dosage amount may vary from user to user; thus, you should talk to your healthcare provider for a safe experience.

The Recommended Doses of Glucuronolactone

According to the experts, you can intake 500mg-600mg of Glucuronolactone supplement per day.

But it would be better to start with a minimal dose and increase it gradually, depending on how you feel.

If you want to take it as a pre-workout supplement, you can ingest 350mg of DGL.

This amount is proven to be effective if taken 10 minutes before the workout sessions.

How to Take Glucuronolactone

You can use Glucuronolactone powder for your daily supplementation. It can be mixed with plain water or milk, whichever you prefer.

Side Effects of Glucuronolactone

You’ll face the side effects of Glucuronolactone when you have an overdose.

Here’s a list of the symptoms you may feel.

  • Stomach Cramps
  • Headache
  • Enhanced heart rate
  • The rise in blood pressure

If users experience disorientation or aggressive behavior, they should stop taking supplements immediately and seek medical attention.


Pregnant women and lactating mothers should consult medical experts before ingesting DGL.

Moreover, if you have any specific health condition, ask your doctor to be on the safe side.

Frequently Asked Questions

Is Glucuronolactone gluten-free?

Yes, it’s a gluten-free ingredient, safe for patients with gluten-related disorders. And this component is also vegan.

How much Glucuronolactone is added to energy drinks?

Though the amount of Glucuronolactone in energy drinks may vary from brand to brand, there are around 600mg available in most beverages.

What are the sources of Glucuronolactone?

Glucuronolactone is naturally found in our bodies and can be taken as supplements. But there’re other sources like chewable coffee, energy-enhancing beverages, and plant gums.

Wrap Up

Finally, we’re at the end of our guide to Glucuronolactone uses, benefits, side effects, and precautions.

As we’ve explained everything in detail, you can now add this supplement to your diet and start enjoying its benefits.

However, make sure you’re staying within the proper dosage. Otherwise, you may go through some severe health conditions, and you don’t want that!

And yes, you can always consult your healthcare provider for safe usage; keep that in mind.


BOYINA, Revathi, and Sujatha DODOALA. “Evaluation of the Neurobehavioural Toxic Effects of Taurine, Glucuronolactone, and Gluconolactone Used in Energy Drinks in Young Rats.” Turkish Journal of Pharmaceutical Sciences 17, no. 6 (2020): 659-666.

Qin, Xinghua, Liu, Binghua, Gao, Feng, Hu, Yuanyuan, Chen, Ziwei, Xu, Jie, and Xing Zhang. “Gluconolactone Alleviates Myocardial Ischemia/Reperfusion Injury and Arrhythmias via Activating PKCε/Extracellular Signal-Regulated Kinase Signaling.” Frontiers in Physiology 13, (2022).

Jordan Kally is a certified strength and conditioning specialist and a registered yoga teacher. Jordan is a gym owner in New York, where he holds personal training/health coaching sessions. He teaches classes on topics which include exercise, weight loss, stress management, sleep, and healthy eating.

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